Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin gene cluster
نویسندگان
چکیده
منابع مشابه
Signals of Historical Interlocus Gene Conversion in Human Segmental Duplications
Standard methods of DNA sequence analysis assume that sequences evolve independently, yet this assumption may not be appropriate for segmental duplications that exchange variants via interlocus gene conversion (IGC). Here, we use high quality multiple sequence alignments from well-annotated segmental duplications to systematically identify IGC signals in the human reference genome. Our analysis...
متن کاملTargeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene.
LH/hCG receptors were disrupted by gene targeting in embryonic stem cells. The disruption resulted in infertility in both sexes. The gonads contained no receptor mRNA or receptor protein. Serum LH levels were greatly elevated, and FSH levels were moderately elevated in both sexes; estradiol and progesterone levels decreased but were not totally suppressed in females; testosterone levels were dr...
متن کاملInterplay of Interlocus Gene Conversion and Crossover in Segmental Duplications Under a Neutral Scenario
Interlocus gene conversion is a major evolutionary force that drives the concerted evolution of duplicated genomic regions. Theoretical models successfully have addressed the effects of interlocus gene conversion and the importance of crossover in the evolutionary fate of gene families and duplications but have not considered complex recombination scenarios, such as the presence of hotspots. To...
متن کاملDetecting gene duplications in the human lineage.
Gene duplications represent an important class of evolutionary events that is likely to have contributed to the unique human phenotype in the short evolutionary time since the human-chimpanzee divergence. With the availability of both human and chimpanzee genome drafts in high coverage re-sequencing assemblies and the high annotation quality of most human genes, it should now be possible to ide...
متن کاملSeminal vesicles are novel sites of luteinizing hormone/human chorionic gonadotropin-receptor gene expression.
The hypothesis that rat seminal vesicles may contain luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors was tested by means of a number of different techniques. Northern blotting demonstrated that rat seminal vesicles contained multiple LH/hCG-receptor transcripts. In situ hybridization revealed that these transcripts were present primarily in the principal epithelial cells l...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2005
ISSN: 1088-9051
DOI: 10.1101/gr.4270505